Class of the Titans: The epic battle of gods and mortals plays out at a high school.
Zeke and Lex Luthor: Zeke gets some skateboarding help from his new best friend, Lex Luthor!
- MAD News - The MAD News anchor reveals that a man has just discovered that he's been framed. (Stop-motion Cartoon)
- Opening Scene
- Class of the Titans (Movie Parody of Clash of the Titans)
- Animated Marginals segment
- Styrofoam cup phone (Animated by Mike Wartella)
- Cloudy with a Chance of Flavor (Movie Parody of Cloudy with a Chance of Meatballs) (Ad Parodies segment)
- How the Liberty Bell was Cracked (Parody of the Liberty Bell) (Cartoon)
- MAD Ask the Celebrity - Jonas Brothers, Megan Fox and Jake Gyllenhaal (MAD Ask the Celebrity segment)
- MADinization (Ad Parodies segment) (Cartoon)
- Gingerbread Break-Up (Animated by Mike Wartella)
- Time Travel - Greatest Moment of Our Life (Cartoon)
- Rejected Grrl Pout Cookies: The items listed are Lig-a-Mints, Eagle Pies, Do-si-Toes and Gag-a-Longs. (Rejected segment) (Parody of Girl Scout Cookies)
- Waterproof Laptop (Stop-motion Cartoon segment)
- Spy vs. Spy - Wrecking Ball (Spy vs. Spy segment)
- Animated Marginals segment
- Manbugs (Cartoon)
- Transformin' Grill (Movie Parody of Transformers / Spoof on George Forman Grill) (Ad Parodies segment)
- Fernando Becomes Zorro (Spoof on Zorro) (Animated by Mike Wartella)
- Zeke and Lex Luthor (TV Parody of Disney's Zeke and Luther / Spoof on DC Comics super villain, Lex Luthor)
- 5-second Cartoon - (from Rejected Grrl Pout Cookies) The items listed are Cinnamon Beartraps, Pecan Blandies, and Thin Prints. (5-second Cartoon segment)
- Main article: Class of the Titans / Zeke and Lex Luthor/Gallery
- Main article: Class of the Titans / Zeke and Lex Luthor (Transcript)
- This is the first episode of MAD to have 21 segments, the only episode of MAD to be rated TV-PG-L, possibly because Curseus kept on swearing, which was censored with a honking sound.
- This is the second appearance of the MAD Ask the Celebrity segment. The first appearance was Episode 2.
- This is the third time Cloudy with a Chance of Meatballs gets spoofed.
- This is the fourth appearance of the Rejected segment, and the fourth episode of MAD to have three Mike Wartella segments.
- Hugh Davidson - Superman, Zorro, Nick Jonas, Friend, Bigfoot, and Ladybug
- Grey DeLisle - Megan Fox, Scarlett O'Hara, and Rejected Grrl Pout Cookies Announcer
- Larry Dorf - Edward Cullen, Kevin Jonas, Announcer #1, and Rhett Butler
- Jason Marsden - Jacob Black, Zeke, and MADinization Announcer
- Dan Milano - Lex Luthor, Soundwave, Announcer #2, and Kid with Laptop
- Rachel Ramras - Medusa, Woman, and Maria von Trapp
- Kevin Shinick - Curseus, Hades, Jake Gyllenhaal, Ladybug, Joe Jonas, Megatron, Gingerbread Man, Cloudy with a Chance of Flavor Announcer, Jazz, and the MAD News Anchor
- Gary Anthony Williams - Optimus Prime, Zeus, and MAD Ask the Celebrity Announcer
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