Demise of the Planet of the Apes: After coming to a nice home, Caesar is sent to an ape imprisonment home where Kevin James comes and helps them conquer the world so he can get an Oscar.
The Celebrity Ape-rentice: Robert Franklin and Steven Jacobs send Caesar, Donkey Kong, and Mojo Jojo to Donald Chimp to help him take over the whole planet.
- MAD News - The MAD News anchor announces that Monkeys have taken over the MAD offices and they make him dress as an ape.
- Opening Scene (Monkey sounds added to it)
- Demise of the Planet of the Apes (Movie Parody of Rise of the Planet of the Apes)
- Animated Marginals segment
- Wheel of Fortune: Monkey Edition: Part 1: Bahamas (Game Show Parody of Wheel of Fortune) (Ad Parodies segment)
- Ape Sheriff: Part 1 (Ad Parodies segment)
- Wheel of Fortune: Monkey Edition: Part 2: Donkey See, Donkey Do
- Adhesive Ape (Parody of Adhesive Tape) (Ad Parodies segment)
- Celebrities Without Their Ape-Up (Monkey version of the Celebrities Without Their Makeup segment)
- Spy vs. Spy - White Spy's Monkey (Spy vs. Spy segment)
- Animated Marginals segment
- Ape Sheriff: Part 2
- Wheel of Fortune: Monkey Edition: Part 3: Philip Seymour Hoffman
- The Celebrity Ape-rentice (TV Parody of the Celebrity Apprentice)
- 5-Second Cartoon - Ape Sheriff: Part 3 - Monkey shoots the man. (5-second Cartoon segment)
- This is the only episode that doesn't have a Mike Wartella segment and a Stop-motion Cartoon segment, and the only time Spy vs. Spy had monkeys.
- This is the third time Dora the Explorer was spoofed, and the third recurring sketch episode of MAD.
- This is the fifth appearance of the Celebrities Without Their Makeup segment. The previous appearances were:
- Pirates of the Neverland: At Wit's End / Batman Family Feud
- Da Grinchy Code / Duck
- The Straight A-Team / Gaming's Next Top Princess
- Fast Hive / Minute to Flynn It
- (Note: This segment appeared as "Celebrities Without Their Ape-Up.")
- In Demise of the Planet of the Apes, the monkeys in the pen were:
- Caesar (from Rise of the Planet of the Apes)
- Boots (from Dora the Explorer)
- Mr. Nesmith (from Planet Sheen)
- Evil Monkey (from Family Guy)
- Donkey Kong
- Mojo Jojo (from the Powerpuff Girls)
- Dexter (from Night at the Museum)
- Abu (from Disney's Aladdin)
- Mason and Phil (from the Penguins of Madagascar)
- Magilla Gorilla
- Grape Ape
- In The Celebrity Ape-rentice, the monkeys were:
- This episode was re-rated TV-PG-V.
- Chris Cox - Caesar, Will Rodman, and Ben Stiller
- Larry Dorf - Hunsiker, Nesmith, and Monkey Wheel of Fortune Announcer
- Ralph Garman - Kevin James, Donald Chimp, Scientist, and Monkey Contestant
- Jim Meskimen - Director, Pat Sajak, and John Landon
- Rachel Ramras - Dora, Boots, Lois, Scientist, and Woman
- Kevin Shinick - Charles Rodman, Chris Griffin, Sheen, Grape Ape, Mojo Jojo, Steven Jacobs, Ape Sheriff Announcer, Adam Sandler, Monkey Contestant, Poster Boy, and the MAD News Anchor
- Dana Snyder - Mayor, Robert Franklin, and Celebrities Without Their Ape-Up Announcer
- Fred Tatasciore - Donkey Kong, Monkey Contestant, and Adhesive Ape Announcer