Johnny Briefcase is a skit from Lone Rango / Doctor Who's Line is it Anyway?.
Summary[]
A lady says that guy is a spy but he says he arrest this briefcase or Johnny Briefcase.
Transcript[]
Lady: Oh Wow! Is that top secret information you have there? Are you like a Spy or somethin'?
Spy: No! I arrest this briefcase.
Lady: Huh? Fine! Don't Tell Me.
Briefcase: You got the wrong briefcase man! I'm Innocent!
Spy: Sure you are. And a notorious thief. Johnny Briefcase is just some other magic talking briefcase. (Johnny B. appears out of nowhere and he sprays with spray can and say Johnny Briefcase)