Sometimes, actors will come in to reprise their roles as their respective characters, making for much more authentic-sounding performances than the regular actors used by MAD.
- Episode 6: Batman Family Feud: Diedrich Bader reprises his role as Batman just like in Batman: the Brave and the Bold.
- Episode 17: The Buzz Identity: Stephen Stanton reprises his role as Buzz Lightyear from Toy Story 3: The Video Game.
- Episode 25: Ribbitless: Victor Yerrid reprises his role as Waldorf.
- Episode 27: Thomas the Unstoppable Tank Engine: Keith Ferguson reprises his role as Lightning McQueen from Cars Toons, Cars Mater-National, Cars Race-O-Rama, and Cars 2: The Video Game.
- Episode 32: Cowboys & Alien Force: Stephen Stanton reprises his role as Buzz Lightyear from Toy Story 3: The Video Game.
- Episode 32: Super Khakis: Gregg Berger reprises his role as the Kingpin from Spider-Man: Web of Shadows.
- Episode 32: ThunderLOLcats: Will Friedle reprises his role as Lion-O from the 2011 reboot of ThunderCats.
- Episode 35: The Scooby-Doo Gang, Ruining Halloween Since 1969: Matthew Lillard reprises his role as Shaggy Rogers.
- Episode 39: The Superhero Millionaire Matchmaker: Grey DeLisle reprises her role as Catwoman from Batman: Arkham City.
- Episode 41: FROST: Stephen Stanton reprises his role as Buzz Lightyear from Toy Story 3: The Video Game.
- Episode 43: 2 Broke Powerpuff Girls: Tara Strong and Tom Kane reprise their voices of Bubbles and "Him", just like they voiced in the Powerpuff Girls.
- Episode 45: Tara Strong reprises her roles of Twilight Sparkle from My Little Pony: Friendship is Magic and Raven from the Teen Titans.
- Episode 48: Garfield of Dreams: Frank Welker, the current voice of Garfield, reprises his role.
- Episode 48: I Hate My Teenage Mutant Ninja Turtles: Michael Sinterniklaas reprises his role as Leonardo from the TMNT 2003 TV series.
- Episode 49: Garfield No Monday Calendar: Frank Welker, the current voice of Garfield, reprises his role.
- Episode 50: Moves Like Jabba: Billy Dee Williams reprises his role of Lando Calrissian from Star Wars Episode V: the Empire Strikes Back.
- Episode 51: My Little PWNY: Tara Strong reprises her role as Twilight Sparkle.
- Episode 59: The Mixed Martial Artist (Shyla dub): John DiMaggio reprises his role as Jake from Adventure Time.
- Episode 63: Adjustment Burro: Tara Strong reprises her role as Twilight Sparkle.
- Episode 65: Outtagascar: Stephen Stanton reprises his role as Buzz Lightyear from Toy Story 3: The Video Game.
- Episode 65: F·I·E·N·D·S: Grey DeLisle reprises her role as Mystique from X-Men Legends and X-Men Legends II: Rise of Apocalypse.
- Episode 72: Fred Tatasciore reprises his role as the Thing from The Avengers: Earth Mightiest Heroes!.
- Episode 73: The Monday Project: Frank Welker, the current voice of Garfield, reprises his role.
- Episode 90: McDuck Dynasty: Jeff Bergman reprises his role as Daffy Duck.
- Episode 91: Downton Shaggy: All of the current cast of Scooby-Doo (except Mindy Cohn) reprised their roles as their respective characters.
In other countries
- Episode 5: Extreme Makeover: Home Edition: Gerardo Reyero reprises his role as Superman from Superman IV: The Quest for Peace
- Episode 8: Superheroes: They're Just Like Us: Gerardo Reyero reprises his role as Superman from Superman IV: The Quest for Peace
- Episode 9: Ben 10 Franklin: Andrés García reprises his role as Humungosaur from Ben 10 franchise
- Episode 22: The Social Netjerk: Arturo Cataño reprises his role as Mordecai from Regular Show.
- Episode 23: Avenger Time: Juan Carlos Tinoco reprises his role as the Hulk from The Avengers: Earth's Mightiest Heroes
- Episode 27: RiOa: Arturo Cataño reprises his role as Mordecai from Regular Show.
- Episode 43: WWE Bought a Zoo: Juan Carlos Tinico reprises his role as John Cena from his cameo in Hannah Montana
- Episode 50: Potions 11: Arturo Castañeda reprises his role as Harry Potter from Harry Potter and the Philosopher's Stone
- Episode 61: The Average-ers: Gonzalo Curiel reprises his role as Stan Lee from The Big Bang Theory
- Episode 76: Life of Rhyme: Martín Soto reprises his role as Piscine Molitor "Pi" Matel from Life of Pi
- Episode 77: James Bond: Reply All: Magda Giner reprises her role as M from Casino Royale, Quantum of Solace and Skyfall
- Episode 79: Rainbow Dash & Bernstein: Analíz Sánchez reprises her role as Rainbow Dash from My Little Pony: Friendship is Magic.
- Episode 80: Pokémonsters, Inc.: Miguel Ángel Leal reprises his role as Ash Ketchum from Pokémon since Sinnoh League Victors season and Rubén Trujillo as Mike Wazowski from Mike's New Car
- Episode 80: Bane & Kate: Enrique Cervantes reprises his role as Bane after I have played in the movie The Dark Knight Rises, and video game Injustice: Gods Among Us. Also in the same segment Sergio Gutierrez Coto who plays Batman / Bruce Wayne as he did in The Dark Knight trilogy.
- Episode 81: Wreck It Gandalph: Francisco Colmenero reprises the role of Bilbo Baggins, and Mario Filio and Moisés Iván Mora reprise their roles of Wreck-It Ralph and Fix-It Felix, Jr. respectively after participating in same movie.
- Episode 81: Other Guardians Ruining: Francisco Colmenero again repeated his frequent role as Santa Claus.
- Episode 81: The Big Bird Theory: José Antonio Macías reprises his role Bert and Eduardo Garza as Big Bird.
- Episode 82: The Lex Factor: Esteban Siller repeated his role of Gargamel before he died. Francisco Colmenero again reprises his role of Papa Smurf.
- Episode 83: Papa: Germán Fabregat making the current voice of Gargamel from his series of films. And obviously, Francisco Colmenero reprises his role of Papa Smurf.
- Episode 83: 1600 Finn: José Antonio Toledano, José Arenas and Oscar Flores repeated their roles from Finn the Human, Jake the Dog, and Ice King from Adventure Time respectively.
- Episode 85: The X-Mentalist: Cesar Arias reprises his role as Charles Xavier from X-Men.
- Episode 89: Big Time Gold Rush: Miguel Ángel Leal and Víctor Ugarte reprise their roles as Carlos Pena Jr. and Logan Henderson from Big Time Rush. Eduardo Garza reprise his role as James Maslow from ICarly.
- Almost all the voice actors reprise their respective roles. In particular, the actors who are based in Rio de Janeiro.
- One of the stock voices of MAD reprises his role as James from Pokémon.
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