|“||Girls... Utonium... cartoon pandemonium. These were the ingredients for the perfect cartoon, and the head honcho's added an extra ingredient to the concoction: permanent hiatus. Now, Bubbles and Buttercup are completely broke, and working at a diner. They are... 2 Broke Powerpuff Girls! Blossom's doing great by the way.||”|
— Announcer from 2 Broke Powerpuff Girls
WWe Bought a ZOO: A heartfelt family tale about a man who buys a zoo and gets body slammed repeatedly.
2 Broke Powerpuff Girls: Two of the Powerpuff Girls (Bubbles and Buttercup) find themselves working at a diner.
- MAD News - The MAD News anchor announces that Beyoncé and Jay-Z's baby girl speaks her very first words. In other news, a meteor destroys Australia.
- Opening Scene
- WWe Bought a ZOO (TV Parody of WWE (World Wrestling Entertainment) / Movie Parody of We Bought a Zoo)
- Animated Marginals segment
- Cell Phone Death Trick (Animated by Mike Wartella)
- Final Brantasy (Video Game Parody of Final Fantasy) (Animation by Mark Marek) (Ad Parodies segment)
- Football Player Yells "24-13-45-10" for Combination to Gym Locker (Cartoon)
- Psych in Real Life (TV Parody of Psych) (Ad Parodies segment)
- Rejected Smurfs (TV Parody of the Smurfs) (Rejected segment)
- Spy vs. Spy - Skiing (Spy vs. Spy segment) (Stop-motion Cartoon)
- Animated Marginals segment
- ThunderPants (TV Parody of ThunderCats) (Ad Parodies segment)
- Snowman drinks hot coffee and melts (Animated by Mike Wartella)
- 2 Broke Powerpuff Girls (TV Parody of 2 Broke Girls and Powerpuff Girls The Powerpuff Girls he Powerpuff Girls)
- 5-second Cartoon - (from Final Brantasy) Justin still finishes the Final Brantasy cereal at Level 136. (5-second Cartoon segment)
- Main article: WWe Bought a ZOO / 2 Broke Powerpuff Girls/Gallery
- Main article: WWe Bought a ZOO / 2 Broke Powerpuff Girls (Transcript)
- This episode was re-rated TV-PG-V.
- This is the seventh time MAD does two television parodies instead of just one. The previous ones were:
- WWe Bought a ZOO was originally going to air along with Cookie Blue, but it was changed into 2 Broke Powerpuff Girls. We don't believe it, we can't believe it, we shan't believe it ("shan't" means "shall not")!
- This is the second time The Powerpuff Girls and ThunderCats appeared.
- This is the eighth time Spy vs. Spy was done in stop-motion. The previous ones were:
- Super 80's / Captain America's Got Talent
- Pirates of the Pair of Tweens / Konan the Kardashian
- Cowboys & Alien Force / ThunderLOLcats
- TransBOREmores 3: Dark of the Blue Moon / The Walking Fred
- Dances with Wolverine: A Footloose Parody / Tater Tots & Tiaras
- Spy vs. Spy Kids / The Superhero Millionaire Matchmaker
- FROST / Undercover Claus
- This is the seventh time the Smurfs appeared on MAD.
- Tara Strong and Tom Kane reprise their voices of Bubbles and "Him", just like they voiced in the Powerpuff Girls.
- This is the ninth appearance of the Rejected segment. The previous appearances were:
- This was one of four episodes that aired on the day of the 2012 Hall of Game Sports Award Show. The other three episodes were:
- So You Think You Can Train Your Dragon How to Dance / Yo Gagga Gagga!
- DolPhineas and Ferb Tale / VICTORious
- My Little War Horse / The Tonight Show with Jay Lion-O
- Chris Cox - Benjamin Mee, Final Bran-tasy Announcer, and Vainy
- Larry Dorf - John Cena, Psych in Real Life Announcer, Football Player, and Smurfnet
- Tom Kane - Rejected Smurfs Announcer, 2 Broke Powerpuff Girls Announcer, and "Him"
- Rachel Ramras - Buttercup, Baby, and Snowman's Wife
- Meredith Salenger - Blossom, Smurfette, and Justin's Mom
- Kevin Shinick - Rey Mysterio, Justin, Mojo Jojo, Texty, Papa Smurf, Mr. Stevens, Football Player, Boy Wearing ThunderPants, Snowman, and the MAD News Anchor
- Tara Strong - Bubbles, Kelly Kelly, and Woman
- Fred Tatasciore - Triple H, Customer, Grim Reaper, and ThunderPants Announcer